Bus tickets between Prague and Berlin cost $18.99 on average, but you can get tickets for as low as $17.99 if you book in advance and/or outside of busy travel times, like weekends and holidays. For a quick, easy and environmentally-conscious choice, travel with FlixBus. We have a large network of 200 destinations, so you can trust us to take Trains from Amsterdam to Prague cover the 440 miles (709 km) long journey taking on average 11 h 17 min with our travel partners like Deutsche Bahn. You can get the cheapest train tickets for this journey for as low as $64 (€55), but the average price of train tickets is $107 (€92). Travelers depart most frequently from Amsterdam Centraal Overview. The InterCity Express (ICE) is a top-of-the range family of high-speed trains run principally by Germany ’s national train provider Deutsche Bahn. Sleek, swift and very comfortable, the ICE is a reliable choice for business and leisure travel. The ultra-modern ICE trains are among the most technologically advanced and comfortable It usually takes around 6 hours 34 minutes to travel the 175 miles (281 km) from Berlin-Charlottenburg to Prague by train, although you can get there in as little as 4 hours 23 minutes on the fastest services. You’ll normally find around 9 trains per day running on this route. You’ll need to make 1 change along the way as there aren't any 66Q44r.